| http://purl.uniprot.org/citations/10731151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10731151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10731151 | http://www.w3.org/2000/01/rdf-schema#comment | "Human immunodeficiency virus (HIV) enters cells in vitro via CD4 and a coreceptor. Which of 15 known coreceptors are important in vivo is poorly defined but may be inferred from disease-modifying mutations, as for CCR5. Here two single nucleotide polymorphisms are described in Caucasians in CX3CR1, an HIV coreceptor and leukocyte chemotactic/adhesion receptor for the chemokine fractalkine. HIV-infected patients homozygous for CX3CR1-I249 M280, a variant haplotype affecting two amino acids (isoleucine-249 and methionine-280), progressed to AIDS more rapidly than those with other haplotypes. Functional CX3CR1 analysis showed that fractalkine binding is reduced among patients homozygous for this particular haplotype. Thus, CX3CR1-I249 M280 is a recessive genetic risk factor in HIV/AIDS."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.287.5461.2274"xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.287.5461.2274"xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Murphy P.M."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Murphy P.M."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Combadiere C."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Combadiere C."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Meyer L."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Meyer L."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Genin E."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Genin E."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Debre P."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Debre P."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Theodorou I."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Theodorou I."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "McDermott D.H."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "McDermott D.H."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Autran B."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Autran B."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Costagliola D."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Costagliola D."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Delfraissy J.-F."xsd:string |
| http://purl.uniprot.org/citations/10731151 | http://purl.uniprot.org/core/author | "Delfraissy J.-F."xsd:string |