| http://purl.uniprot.org/citations/10748143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10748143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10748143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/10748143 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression cloning of a cDNA for globotriaosylceramide (Gb3)/CD77 synthase (alpha1,4-galactosyltransferase) was achieved using an anti-Gb3 antibody and mouse L cells as a recipient cell line for the transfection. The isolated cDNA clone designated pVTR1 predicted a type II membrane protein with 19 amino acids of cytoplasmic domain, 26 amino acids of transmembrane region, and a catalytic domain with 308 amino acids. Introduction of the cDNA clone into L cells resulted in the neosynthesis of Gb3/CD77, and the extracts of the transfectant cells showed alpha1, 4-galactosyltransferase activity only on lactosylceramide and galactosylceramide. In Northern blotting, a 2.3-kilobase mRNA was strongly expressed in heart, kidney, spleen, and placenta and weakly in colon, small intestine, and brain. Transfection of the cDNA into L cells resulted in the constitution of sensitivity to the apoptosis with Shiga-like toxins (verotoxins). Since Gb3/CD77 synthase initiates the synthesis of globo series glycolipids, the isolation of this cDNA will make possible further investigations into the function of its important series of glycolipids."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m909620199"xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m909620199"xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Yokoyama K."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Yokoyama K."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Furukawa K."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Furukawa K."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Ohta M."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Ohta M."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Okajima T."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Okajima T."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Fukumoto S."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Fukumoto S."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Furukawa K.'"xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Furukawa K.'"xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Kojima Y."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Kojima Y."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Urano T."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Urano T."xsd:string |
| http://purl.uniprot.org/citations/10748143 | http://purl.uniprot.org/core/author | "Wiels J."xsd:string |