| http://purl.uniprot.org/citations/10758161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10758161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10758161 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates cellular and systemic homeostatic responses to reduced O(2) availability in mammals, including angiogenesis, erythropoiesis, and glycolysis. HIF-1 activity is controlled by the O(2)-regulated expression of the HIF-1alpha subunit. Under nonhypoxic conditions, HIF-1alpha protein is subject to ubiquitination and proteasomal degradation. Here we report that missense mutations and/or deletions involving several different regions of HIF-1alpha result in constitutive expression and transcriptional activity in nonhypoxic cells. We demonstrate that hypoxia results in decreased ubiquitination of HIF-1alpha and that missense mutations increase HIF-1alpha expression under nonhypoxic conditions by blocking ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.080072497"xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.080072497"xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/author | "Sutter C.H."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/author | "Sutter C.H."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/author | "Semenza G.L."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/author | "Semenza G.L."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/author | "Laughner E."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/author | "Laughner E."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/pages | "4748-4753"xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/pages | "4748-4753"xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/title | "Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/title | "Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations."xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/volume | "97"xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://purl.uniprot.org/core/volume | "97"xsd:string |
| http://purl.uniprot.org/citations/10758161 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10758161 |
| http://purl.uniprot.org/citations/10758161 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10758161 |
| http://purl.uniprot.org/citations/10758161 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10758161 |
| http://purl.uniprot.org/citations/10758161 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10758161 |