Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization.

Sood R., Makalowska I., Carpten J.D., Robbins C.M., Stephan D.A., Connors T.D., Morgenbesser S.D., Su K., Pinkett H.W., Graham C.L., Quesenberry M.I., Baxevanis A.D., Klinger K.W., Trent J.M., Bonner T.I.

Ral GDP dissociation stimulator (RalGDS) and its family members RGL, RLF and RGL2 are involved in Ras and Ral signaling pathways as downstream effector proteins. Here we report the precise localization and cloning of two forms of human RGL gene differing at the amino terminus. Transcript A, cloned from liver cDNA libraries has the same amino terminus as the mouse RGL, whereas transcript B cloned from brain has a substitution of 45 amino acids for the first nine amino acids. At the genomic level, exon 1 of transcript A is replaced by two alternative exons (1B1 and 1B2) in transcript B. Both forms share exons 2 through 18. The human RGL protein shares 94% amino acid identity with the mouse protein. Northern blot analysis shows that human RGL is expressed in a wide variety of tissues with strong expression being seen in the heart, brain, kidney, spleen and testis.

Biochim. Biophys. Acta 1491:285-288(2000) [PubMed] [Europe PMC]

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again