| http://purl.uniprot.org/citations/10771424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10771424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10771424 | http://www.w3.org/2000/01/rdf-schema#comment | "The structure of human MRP8 in the calcium-bound form was determined at 1.9 A resolution by X-ray crystallography. The structure was initially solved by MAD phasing of an ytterbium-substituted crystal and was refined against data obtained from a Ca(2+)-bound crystal. The dimeric form of MRP8 was stabilized by hydrophobic interactions between mutually wrapped helices. There were two EF-hand motifs per monomer and each EF-hand bound one Ca(2+) with a different affinity [the affinity of the C-terminal EF-hand (EF-2) for Ca(2+) was stronger than that of the N-terminal EF-hand (EF-1)]. Furthermore, replacement with Yb(3+) occurred in the C-terminal EF-hand only, suggesting a more flexible nature for EF-2 than for EF-1. This, combined with previous observations that the helix in EF-2 (helix III) undergoes a large conformational change upon calcium binding, suggests that the C-terminal EF-hand (EF-2) plays a role as a trigger for Ca(2+)-induced conformational change."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444900002833"xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444900002833"xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/author | "Ishikawa K."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/author | "Ishikawa K."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/author | "Nakagawa A."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/author | "Nakagawa A."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/author | "Tanaka I."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/author | "Tanaka I."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/author | "Nishihira J."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/author | "Nishihira J."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/pages | "559-566"xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/pages | "559-566"xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/title | "The structure of human MRP8, a member of the S100 calcium-binding protein family, by MAD phasing at 1.9 A resolution."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/title | "The structure of human MRP8, a member of the S100 calcium-binding protein family, by MAD phasing at 1.9 A resolution."xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/10771424 | http://purl.uniprot.org/core/volume | "56"xsd:string |