| http://purl.uniprot.org/citations/10772654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10772654 | http://www.w3.org/2000/01/rdf-schema#comment | "The oxidative conversion of LDL into an atherogenic form is considered a pivotal event in the development of cardiovascular disease. Recent studies have identified reactive nitrogen species generated by monocytes by way of the myeloperoxidase-hydrogen peroxide-nitrite (MPO-H(2)O(2)-NO(2)(-)) system as a novel mechanism for converting LDL into a high-uptake form (NO(2)-LDL) for macrophages. We now identify the scavenger receptor CD36 as the major receptor responsible for high-affinity and saturable cellular recognition of NO(2)-LDL by murine and human macrophages. Using cells stably transfected with CD36, CD36-specific blocking mAbs, and CD36-null macrophages, we demonstrated CD36-dependent binding, cholesterol loading, and macrophage foam cell formation after exposure to NO(2)-LDL. Modification of LDL by the MPO-H(2)O(2)-NO(2)(-) system in the presence of up to 80% lipoprotein-deficient serum (LPDS) still resulted in the conversion of the lipoprotein into a high-uptake form for macrophages, whereas addition of less than 5% LPDS totally blocked Cu(2+)-catalyzed LDL oxidation and conversion into a ligand for CD36. Competition studies demonstrated that lipid oxidation products derived from 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine can serve as essential moieties on NO(2)-LDL recognized by CD36. Collectively, these results suggest that MPO-dependent conversion of LDL into a ligand for CD36 is a likely pathway for generating foam cells in vivo. MPO secreted from activated phagocytes may also tag phospholipid-containing targets for removal by CD36-positive cells."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci8574"xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/author | "Febbraio M."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/author | "Silverstein R.L."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/author | "Schmitt D."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/author | "Hazen S.L."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/author | "Frazier W.A."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/author | "Podrez E.A."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/author | "Sheibani N."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/author | "Cohen P.A."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/author | "Hajjar D.P."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/author | "Hoff H.F."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/pages | "1095-1108"xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/title | "Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species."xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/10772654 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10772654 |
| http://purl.uniprot.org/citations/10772654 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10772654 |
| http://purl.uniprot.org/uniprot/P16671#attribution-4E4A41A21D894CB1EA338E1C224ABEB5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10772654 |
| http://purl.uniprot.org/uniprot/P16671#attribution-F18EBD75182ED0326C24565739ECA4F3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10772654 |
| http://purl.uniprot.org/uniprot/Q08857#attribution-3233A129AC775B03EDDCD87C87616659 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10772654 |
| http://purl.uniprot.org/uniprot/Q08857#attribution-F18EBD75182ED0326C24565739ECA4F3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10772654 |
| http://purl.uniprot.org/uniprot/P05164#attribution-4E4A41A21D894CB1EA338E1C224ABEB5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10772654 |