| http://purl.uniprot.org/citations/10778856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10778856 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurodegenerative disorders like Huntington's disease (HD) are characterized by progressive and putative irreversible clinical and neuropathological symptoms, including neuronal protein aggregates. Conditional transgenic models of neurodegenerative diseases therefore could be a powerful means to explore the relationship between mutant protein expression and progression of the disease. We have created a conditional model of HD by using the tet-regulatable system. Mice expressing a mutated huntingtin fragment demonstrate neuronal inclusions, characteristic neuropathology, and progressive motor dysfunction. Blockade of expression in symptomatic mice leads to a disappearance of inclusions and an amelioration of the behavioral phenotype. We thus demonstrate that a continuous influx of the mutant protein is required to maintain inclusions and symptoms, raising the possibility that HD may be reversible."xsd:string |
| http://purl.uniprot.org/citations/10778856 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80623-6"xsd:string |
| http://purl.uniprot.org/citations/10778856 | http://purl.uniprot.org/core/author | "Yamamoto A."xsd:string |
| http://purl.uniprot.org/citations/10778856 | http://purl.uniprot.org/core/author | "Hen R."xsd:string |
| http://purl.uniprot.org/citations/10778856 | http://purl.uniprot.org/core/author | "Lucas J.J."xsd:string |
| http://purl.uniprot.org/citations/10778856 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10778856 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/10778856 | http://purl.uniprot.org/core/pages | "57-66"xsd:string |
| http://purl.uniprot.org/citations/10778856 | http://purl.uniprot.org/core/title | "Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease."xsd:string |
| http://purl.uniprot.org/citations/10778856 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/10778856 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10778856 |
| http://purl.uniprot.org/citations/10778856 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10778856 |
| http://purl.uniprot.org/uniprot/P42859#attribution-CDBC9F2ED515DD39C955CA7EF6921C78 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10778856 |
| http://purl.uniprot.org/uniprot/#_P42859-mappedCitation-10778856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10778856 |
| http://purl.uniprot.org/uniprot/#_G3X9H5-mappedCitation-10778856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10778856 |
| http://purl.uniprot.org/uniprot/P42859 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10778856 |
| http://purl.uniprot.org/uniprot/G3X9H5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10778856 |