| http://purl.uniprot.org/citations/10783893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10783893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10783893 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphorylation of IkappaB by the IkappaB kinase (IKK) complex is a critical step leading to IkappaB degradation and activation of transcription factor NF-kappaB. The IKK complex contains two catalytic subunits, IKKalpha and IKKbeta, the latter being indispensable for NF-kappaB activation by pro-inflammatory cytokines. Although IKK is activated by phosphorylation of the IKKbeta activation loop, the physiological IKK kinases that mediate responses to extracellular stimuli remain obscure. Here we describe an IKK-related kinase, named NAK (NF-kappaB-activating kinase), that can activate IKK through direct phosphorylation. NAK induces IkappaB degradation and NF-kappaB activity through IKKbeta. Endogenous NAK is activated by phorbol ester tumour promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kappaB by protein kinase C-epsilon (PKCepsilon). Thus, NAK is an IKK kinase that may mediate IKK and NF-kappaB activation in response to growth factors that stimulate PKCepsilon activity."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.org/dc/terms/identifier | "doi:10.1038/35008109"xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.org/dc/terms/identifier | "doi:10.1038/35008109"xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Ikeda K."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Ikeda K."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Nakanishi M."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Nakanishi M."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Kaneko Y."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Kaneko Y."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Nimura Y."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Nimura Y."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Hatakeyama S."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Hatakeyama S."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Motoyama N."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Motoyama N."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Delhase M."xsd:string |
| http://purl.uniprot.org/citations/10783893 | http://purl.uniprot.org/core/author | "Delhase M."xsd:string |