| http://purl.uniprot.org/citations/10806474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10806474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10806474 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we show that cells lacking focal adhesion kinase (FAK) are refractory to motility signals from platelet-derived and epidermal growth factors (PDGF and EGF respectively), and that stable re-expression of FAK rescues these defects. FAK associates with activated PDGF- and EGF-receptor (PDGFR and EGFR) signalling complexes, and expression of the band-4.1-like domain at the FAK amino terminus is sufficient to mediate an interaction with activated EGFR. However, efficient EGF-stimulated cell migration also requires FAK to be targeted, by its carboxy-terminal domain, to sites of integrin-receptor clustering. Although the kinase activity of FAK is not needed to promote PDGF- or EGF-stimulated cell motility, kinase-inactive FAK is transphosphorylated at the indispensable Src-kinase-binding site, FAK Y397, after EGF stimulation of cells. Our results establish that FAK is an important receptor-proximal link between growth-factor-receptor and integrin signalling pathways."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.org/dc/terms/identifier | "doi:10.1038/35010517"xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.org/dc/terms/identifier | "doi:10.1038/35010517"xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Schaefer E."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Schaefer E."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Schlaepfer D.D."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Schlaepfer D.D."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Ilic D."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Ilic D."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Hauck C.R."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Hauck C.R."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Damsky C.H."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Damsky C.H."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Klingbeil C.K."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Klingbeil C.K."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Sieg D.J."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/author | "Sieg D.J."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/pages | "249-256"xsd:string |
| http://purl.uniprot.org/citations/10806474 | http://purl.uniprot.org/core/pages | "249-256"xsd:string |