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http://purl.uniprot.org/citations/10806482http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10806482http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10806482http://www.w3.org/2000/01/rdf-schema#comment"Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.org/dc/terms/identifier"doi:10.1038/35010579"xsd:string
http://purl.uniprot.org/citations/10806482http://purl.org/dc/terms/identifier"doi:10.1038/35010579"xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Betsholtz C."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Betsholtz C."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Eriksson U."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Eriksson U."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Heldin C.H."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Heldin C.H."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Aase K."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Aase K."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Alitalo K."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Alitalo K."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Karlsson L."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Karlsson L."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Soriano P."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Soriano P."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Abramsson A."xsd:string
http://purl.uniprot.org/citations/10806482http://purl.uniprot.org/core/author"Abramsson A."xsd:string