| http://purl.uniprot.org/citations/10807576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10807576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10807576 | http://www.w3.org/2000/01/rdf-schema#comment | "A critical function of tumor suppressor p53 is the induction of apoptosis in cells exposed to noxious stresses. We report a previously unidentified pro-apoptotic gene, Noxa. Expression of Noxa induction in primary mouse cells exposed to x-ray irradiation was dependent on p53. Noxa encodes a Bcl-2 homology 3 (BH3)-only member of the Bcl-2 family of proteins; this member contains the BH3 region but not other BH domains. When ectopically expressed, Noxa underwent BH3 motif-dependent localization to mitochondria and interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. We also demonstrate that blocking the endogenous Noxa induction results in the suppression of apoptosis. Noxa may thus represent a mediator of p53-dependent apoptosis."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.288.5468.1053"xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.288.5468.1053"xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Tanaka N."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Tanaka N."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Yamashita T."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Yamashita T."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Taniguchi T."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Taniguchi T."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Ohki R."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Ohki R."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Tokino T."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Tokino T."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Murasawa H."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Murasawa H."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Nemoto J."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Nemoto J."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Oda E."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Oda E."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Shibue T."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/author | "Shibue T."xsd:string |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10807576 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |