| http://purl.uniprot.org/citations/10830168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10830168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10830168 | http://www.w3.org/2000/01/rdf-schema#comment | "To elucidate the structural determinants governing specificity in fibroblast growth factor (FGF) signaling, we have determined the crystal structures of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor 1 (FGFR1) and FGFR2, respectively. Highly conserved FGF-D2 and FGF-linker (between D2-D3) interfaces define a general binding site for all FGF-FGFR complexes. Specificity is achieved through interactions between the N-terminal and central regions of FGFs and two loop regions in D3 that are subject to alternative splicing. These structures provide a molecular basis for FGF1 as a universal FGFR ligand and for modulation of FGF-FGFR specificity through primary sequence variations and alternative splicing."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80851-x"xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80851-x"xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/author | "Plotnikov A.N."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/author | "Plotnikov A.N."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/author | "Schlessinger J."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/author | "Schlessinger J."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/author | "Hubbard S.R."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/author | "Hubbard S.R."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/author | "Mohammadi M."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/author | "Mohammadi M."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/pages | "413-424"xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/pages | "413-424"xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/title | "Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/title | "Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity."xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/10830168 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10830168 |
| http://purl.uniprot.org/citations/10830168 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10830168 |