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| http://purl.uniprot.org/citations/10846166 | http://www.w3.org/2000/01/rdf-schema#comment | "Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1alpha transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum."xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.288.5472.1832"xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/author | "Hashimoto K."xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/author | "Katsuki M."xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/author | "Nakao K."xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/author | "Aiba A."xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/author | "Kano M."xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/author | "Shigemoto R."xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/author | "Yanagihara D."xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/author | "Ichise T."xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/pages | "1832-1835"xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/title | "mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination."xsd:string |
| http://purl.uniprot.org/citations/10846166 | http://purl.uniprot.org/core/volume | "288"xsd:string |
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