| http://purl.uniprot.org/citations/10848592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10848592 | http://www.w3.org/2000/01/rdf-schema#comment | "In skeletal myoblasts, Ras has been considered to be a strong inhibitor of myogenesis. Here, we demonstrate that Ras is involved also in the chemotactic response of skeletal myoblasts. Expression of a dominant-negative mutant of Ras inhibited chemotaxis of C2C12 myoblasts in response to basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and insulin-like growth factor 1 (IGF-1), key regulators of limb muscle development and skeletal muscle regeneration. A dominant-negative Ral also decreased chemotactic migration by these growth factors, while inhibitors for phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase (MEK) showed no effect. Activation of the Ras-Ral pathway by expression of an activated mutant of either Ras, the guanine-nucleotide dissociation stimulator for Ral, or Ral resulted in increased motility of myoblasts. The ability of Ral to stimulate motility was reduced by introduction of a mutation which prevents binding to Ral-binding protein 1 or phospholipase D. These results suggest that the Ras-Ral pathway is essential for the migration of myoblasts. Furthermore, we found that Ras and Ral are activated in C2C12 cells by bFGF, HGF and IGF-1 and that the Ral activation is regulated by the Ras- and the intracellular Ca(2+)-mediated pathways. Taken together, our data indicate that Ras and Ral regulate the chemotactic migration of skeletal muscle progenitors."xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.13.4658-4665.2000"xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/author | "Yamazaki Y."xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/author | "Suzuki J."xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/author | "Kaziro Y."xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/author | "Koide H."xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/author | "Guang L."xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/pages | "4658-4665"xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/title | "Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts."xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10848592 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10848592 |
| http://purl.uniprot.org/citations/10848592 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10848592 |
| http://purl.uniprot.org/uniprot/P09038#attribution-B0D6C4469ECDF2F0F2FE94FADC3882C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10848592 |
| http://purl.uniprot.org/uniprot/P05019#attribution-B0D6C4469ECDF2F0F2FE94FADC3882C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10848592 |
| http://purl.uniprot.org/uniprot/Q13393#attribution-B0D6C4469ECDF2F0F2FE94FADC3882C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10848592 |
| http://purl.uniprot.org/uniprot/P01112#attribution-B0D6C4469ECDF2F0F2FE94FADC3882C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10848592 |
| http://purl.uniprot.org/uniprot/P11233#attribution-B0D6C4469ECDF2F0F2FE94FADC3882C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10848592 |
| http://purl.uniprot.org/uniprot/Q15311#attribution-B0D6C4469ECDF2F0F2FE94FADC3882C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10848592 |