| http://purl.uniprot.org/citations/10891471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10891471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10891471 | http://www.w3.org/2000/01/rdf-schema#comment | "The Kell blood group protein is a zinc endopeptidase that yields endothelin-3, a potent bioactive peptide, by cleavage of big endothelin-3, a larger intermediate precursor. On red cells, Kell protein is linked by a single disulfide bond to XK, a protein that traverses the membrane 10 times and whose absence, as occurs in the McLeod phenotype, is associated with a set of clinical symptoms that include nerve and muscle disorders and red cell acanthocytosis. Previous studies indicated that Kell is primarily expressed in erythroid tissues, whereas XK has a wider tissue distribution. The tissue distribution of Kell protein has been further investigated by Northern blot analysis, PCR-screening of tissue complementary DNAs (cDNAs), and Western immunoblots. Screening of an RNA dot-blot panel confirmed that Kell is primarily expressed in erythroid tissues but is also expressed in a near equal amount in testis, with weaker expression in a large number of other tissues. PCR-screening of cDNAs from different tissues and DNA sequencing of the products gave similar results. In 2 of the nonerythroid tissues tested, testis and skeletal muscle, Kell protein was detected by Western immunoblotting. In skeletal muscle, isolation of XK with a specific antibody coisolated Kell protein. These studies demonstrate that Kell is expressed in both erythroid and nonerythroid tissues and is associated with XK."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/author | "Russo D."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/author | "Russo D."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/author | "Redman C.M."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/author | "Redman C.M."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/pages | "340-346"xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/pages | "340-346"xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/title | "Expression of Kell blood group protein in nonerythroid tissues."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/title | "Expression of Kell blood group protein in nonerythroid tissues."xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10891471 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10891471 |
| http://purl.uniprot.org/citations/10891471 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10891471 |
| http://purl.uniprot.org/citations/10891471 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10891471 |
| http://purl.uniprot.org/citations/10891471 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10891471 |