| http://purl.uniprot.org/citations/10903326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10903326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10903326 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipoprotein glomerulopathy (LPG) is a unique renal disease characterized by thrombus-like substances in markedly dilated glomerular capillaries, dysbetalipoproteinemia, and elevated plasma concentrations of apoE. Recent studies identified several apoE mutations in patients with LPG, including apoE2(R145P) Sendai (apoE-Sendai). Virus-mediated transduction of apoE-Sendai in apoE-deficient hypercholesterolemic mice resulted in insufficient correction of hypercholesterolemia and a marked and temporal induction of plasma triglyceride levels. In vitro binding studies showed that apoE-Sendai has a reduced affinity for the low density lipoprotein receptor, suggesting that dysbetalipoproteinemia in LPG is caused by the apoE mutation. Furthermore, histological examination revealed marked intraglomerular depositions of apoE-containing lipoproteins in mice injected with apoE-Sendai virus. These LPG-like depositions were detected 6 days after virus injection and were sustained for at least 60 days. Our results demonstrated that apoE-Sendai is an etiological cause of LPG."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m005906200"xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m005906200"xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Usui S."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Usui S."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Toyota T."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Toyota T."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Sasaki J."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Sasaki J."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Yamamoto T.T."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Yamamoto T.T."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Magoori K."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Magoori K."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Sasano H."xsd:string |
| http://purl.uniprot.org/citations/10903326 | http://purl.uniprot.org/core/author | "Sasano H."xsd:string |