| http://purl.uniprot.org/citations/10903733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10903733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10903733 | http://www.w3.org/2000/01/rdf-schema#comment | "BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes. Previously, we reported in a human malignant myeloma cell line that BCMA is not primarily present on the cell surface but lies in a perinuclear structure that partially overlaps the Golgi apparatus. We now show that in transiently or stably transfected cells, BCMA is located on the cell surface, as well as in a perinulear Golgi-like structure. We also show that overexpression of BCMA in 293 cells activates NF-kappa B, Elk-1, the c-Jun N-terminal kinase, and the p38 mitogen-activated protein kinase. Coimmunoprecipitation experiments performed in transfected cells showed that BCMA associates with TNFR-associated factor (TRAF) 1, TRAF2, and TRAF3 adaptor proteins. Analysis of deletion mutants of the intracytoplasmic tail of BCMA showed that the 25-aa protein segment, from position 119 to 143, conserved between mouse and human BCMA, is essential for its association with the TRAFs and the activation of NF-kappa B, Elk-1, and c-Jun N-terminal kinase. BCMA belongs structurally to the TNFR family. Its unique TNFR motif corresponds to a variant motif present in the fourth repeat of the TNFRI molecule. This study confirms that BCMA is a functional member of the TNFR superfamily. Furthermore, as BCMA is lacking a "death domain" and its overexpression activates NF-kappa B and c-Jun N-terminal kinase, we can reasonably hypothesize that upon binding of its corresponding ligand BCMA transduces signals for cell survival and proliferation."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.3.1322"xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.3.1322"xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Inoue J."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Inoue J."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Hatzoglou A."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Hatzoglou A."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Roussel J."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Roussel J."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Rogier E."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Rogier E."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Devergne O."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Devergne O."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Tsapis A."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Tsapis A."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Bourgeade M.-F."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Bourgeade M.-F."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Madry C."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/author | "Madry C."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10903733 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |