| http://purl.uniprot.org/citations/10913172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10913172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10913172 | http://www.w3.org/2000/01/rdf-schema#comment | "RAD24 and RFC5 are required for DNA damage checkpoint control in the budding yeast Saccharomyces cerevisiae. Rad24 is structurally related to replication factor C (RFC) subunits and associates with RFC subunits Rfc2, Rfc3, Rfc4, and Rfc5. rad24Delta mutants are defective in all the G(1)-, S-, and G(2)/M-phase DNA damage checkpoints, whereas the rfc5-1 mutant is impaired only in the S-phase DNA damage checkpoint. Both the RFC subunits and Rad24 contain a consensus sequence for nucleoside triphosphate (NTP) binding. To determine whether the NTP-binding motif is important for Rad24 function, we mutated the conserved lysine(115) residue in this motif. The rad24-K115E mutation, which changes lysine to glutamate, confers a complete loss-of-function phenotype, while the rad24-K115R mutation, which changes lysine to arginine, shows no apparent phenotype. Although neither rfc5-1 nor rad24-K115R single mutants are defective in the G(1)- and G(2)/M-phase DNA damage checkpoints, rfc5-1 rad24-K115R double mutants become defective in these checkpoints. Coimmunoprecipitation experiments revealed that Rad24(K115R) fails to interact with the RFC proteins in rfc5-1 mutants. Together, these results indicate that RFC5, like RAD24, functions in all the G(1)-, S- and G(2)/M-phase DNA damage checkpoints and suggest that the interaction of Rad24 with the RFC proteins is essential for DNA damage checkpoint control."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.16.5888-5896.2000"xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.16.5888-5896.2000"xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/author | "Sugimoto K."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/author | "Sugimoto K."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/author | "Naiki T."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/author | "Naiki T."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/author | "Shimomura T."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/author | "Shimomura T."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/pages | "5888-5896"xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/pages | "5888-5896"xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/title | "Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/title | "Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10913172 | http://purl.uniprot.org/core/volume | "20"xsd:string |