| http://purl.uniprot.org/citations/10918594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10918594 | http://www.w3.org/2000/01/rdf-schema#comment | "Four human cell lines derived from Ewing's sarcoma, EW-7, EW-1, COH and ORS, were investigated to establish the effects of human recombinant interferon-alpha2a and human recombinant interferon-beta on cell proliferation and apoptosis. All four cell lines were much more sensitive to the antiproliferative effects of IFN-beta than of IFN-alpha. Analysis of the early signals triggered by IFN-alpha and IFN-beta demonstrated that the two IFNs were similarly effective in inducing tyrosine phosphorylation of the Jak-1 and Tyk-2 kinases and the transcription factors Stat-1 and Stat-2. Interestingly, an additional rapid phosphorylation of Stat-1 on serine was observed after IFN-beta treatment, with concomitant activation of p38 mitogen-activated protein kinase. In these cells, Stat-1 Ser727 phosphorylation in response to IFN-beta was found to be impaired by p38 MAPkinase inhibitor (SB203580). IFN-beta induced the formation of the Interferon Stimulated Gene Factor 3 complex more efficiently than IFN-alpha, as well as sustained induction of IRF-1, which may account for its greater induction of 2'5'oligo(A)synthetase and greater inhibition of cell proliferation. IFN-beta, but not IFN-alpha, induced apoptosis in wild-type p53 EW-7 and COH cell lines, but not in the mutated p53 EW-1 or ORS cell lines. The apoptosis induced by IFN-beta in EW-7 and COH cell lines appeared to be mediated by IRF-1 and involved the activation of caspase-7. Ectopic expression of IRF-1 induced apoptosis in all four cell lines which correlated with the activation of caspase-7 and with the downregulation of the Bcl-2 oncoprotein, as observed for IFN-beta-induced apoptosis in parental EW-7 and COH cell lines."xsd:string |
| http://purl.uniprot.org/citations/10918594 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203670"xsd:string |
| http://purl.uniprot.org/citations/10918594 | http://purl.uniprot.org/core/author | "Hiscott J."xsd:string |
| http://purl.uniprot.org/citations/10918594 | http://purl.uniprot.org/core/author | "Delattre O."xsd:string |
| http://purl.uniprot.org/citations/10918594 | http://purl.uniprot.org/core/author | "Wietzerbin J."xsd:string |
| http://purl.uniprot.org/citations/10918594 | http://purl.uniprot.org/core/author | "Sanceau J."xsd:string |
| http://purl.uniprot.org/citations/10918594 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10918594 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10918594 | http://purl.uniprot.org/core/pages | "3372-3383"xsd:string |
| http://purl.uniprot.org/citations/10918594 | http://purl.uniprot.org/core/title | "IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7."xsd:string |
| http://purl.uniprot.org/citations/10918594 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10918594 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10918594 |
| http://purl.uniprot.org/citations/10918594 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10918594 |
| http://purl.uniprot.org/uniprot/P01574#attribution-2BEAAEB6B3332B1D8DBC20FF6C85457E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10918594 |
| http://purl.uniprot.org/uniprot/#_P42224-mappedCitation-10918594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10918594 |
| http://purl.uniprot.org/uniprot/P42224 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10918594 |