| http://purl.uniprot.org/citations/10921920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10921920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10921920 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Catenin is efficiently phosphorylated by glycogen synthase kinase-3beta in the Axin complex in the cytoplasm, resulting in the down-regulation. In response to Wnt, beta-catenin is stabilized and translocated into the nucleus where it stimulates gene expression through Tcf/Lef. Here we report a novel protein, designated Duplin (for axis duplication inhibitor), which negatively regulates the function of beta-catenin in the nucleus. Duplin was located in the nucleus. Duplin bound directly to the Armadillo repeats of beta-catenin, thereby inhibiting the binding of Tcf to beta-catenin. It did not affect the stability of beta-catenin but inhibited Wnt- or beta-catenin-dependent Tcf activation. Furthermore, expression of Duplin in Xenopus embryos inhibited the axis formation and beta-catenin-dependent axis duplication, and prevented the beta-catenin's ability to rescue ventralizing phenotypes induced by ultraviolet light irradiation. Thus, Duplin is a nuclear protein that inhibits beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m004089200"xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m004089200"xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Takada S."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Takada S."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Kishida M."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Kishida M."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Asashima M."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Asashima M."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Fukui A."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Fukui A."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Michiue T."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Michiue T."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Hino S."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Hino S."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Kishida S."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Kishida S."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Sakamoto I."xsd:string |
| http://purl.uniprot.org/citations/10921920 | http://purl.uniprot.org/core/author | "Sakamoto I."xsd:string |