| http://purl.uniprot.org/citations/10950869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10950869 | http://www.w3.org/2000/01/rdf-schema#comment | "TNFR1/Fas engagement results in the cleavage of cytosolic BID to truncated tBID, which translocates to mitochondria. Immunodepletion and gene disruption indicate BID is required for cytochrome c release. Surprisingly, the three-dimensional structure of this BH3 domain-only molecule revealed two hydrophobic alpha-helices suggesting tBID itself might be a pore-forming protein. Instead, we demonstrate that tBID functions as a membrane-targeted death ligand in which an intact BH3 domain is required for cytochrome c release, but not for targeting. Bak-deficient mitochondria and blocking antibodies reveal tBID binds to its mitochondrial partner BAK to release cytochrome c, a process independent of permeability transition. Activated tBID results in an allosteric activation of BAK, inducing its intramembranous oligomerization into a proposed pore for cytochrome c efflux, integrating the pathway from death receptors to cell demise."xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/author | "Lindsten T."xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/author | "Thompson C.B."xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/author | "Mootha V.K."xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/author | "Gross A."xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/author | "Weiler S."xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/author | "Korsmeyer S.J."xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/author | "Wei M.C."xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/author | "Ashiya M."xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/pages | "2060-2071"xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/title | "tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c."xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/10950869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10950869 |
| http://purl.uniprot.org/citations/10950869 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10950869 |
| http://purl.uniprot.org/uniprot/P70444#attribution-C02F70FF5BB4A08E91FF1A460AF3AAD7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10950869 |
| http://purl.uniprot.org/uniprot/P70444#attribution-C922136C69AB2885A076D395F2E3823D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10950869 |
| http://purl.uniprot.org/uniprot/O08734#attribution-0A6C02E5A534D66C3AE37AE9F8262D82 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10950869 |
| http://purl.uniprot.org/uniprot/O08734#attribution-364E4ACD776A88445B64CFF4E11A8756 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10950869 |
| http://purl.uniprot.org/uniprot/O08734#attribution-4C88BA004C7AA512D8CD239FE75BE750 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10950869 |
| http://purl.uniprot.org/uniprot/O08734#attribution-C922136C69AB2885A076D395F2E3823D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10950869 |
| http://purl.uniprot.org/uniprot/P25446#attribution-648CFC410078B97B6DE3FCD315C53D53 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10950869 |
| http://purl.uniprot.org/uniprot/P25446#attribution-C922136C69AB2885A076D395F2E3823D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10950869 |