| http://purl.uniprot.org/citations/10970852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10970852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10970852 | http://www.w3.org/2000/01/rdf-schema#comment | "WAVE proteins are members of the Wiskott-Aldrich syndrome protein (WASP) family of scaffolding proteins that coordinate actin reorganization by coupling Rho-related small molecular weight GTPases to the mobilization of the Arp2/3 complex. We identified WAVE-1 in a screen for rat brain A kinase-anchoring proteins (AKAPs), which bind to the SH3 domain of the Abelson tyrosine kinase (Abl). Recombinant WAVE-1 interacts with cAMP-dependent protein kinase (PKA) and Abl kinases when expressed in HEK-293 cells, and both enzymes co-purify with endogenous WAVE from brain extracts. Mapping studies have defined binding sites for each kinase. Competition experiments suggest that the PKA-WAVE-1 interaction may be regulated by actin as the kinase binds to a site overlapping a verprolin homology region, which has been shown to interact with actin. Immunocytochemical analyses in Swiss 3T3 fibroblasts suggest that the WAVE-1 kinase scaffold is assembled dynamically as WAVE, PKA and Abl translocate to sites of actin reorganization in response to platelet-derived growth factor treatment. Thus, we propose a previously unrecognized function for WAVE-1 as an actin-associated scaffolding protein that recruits PKA and Abl."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.17.4589"xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.17.4589"xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/author | "Scott J.D."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/author | "Scott J.D."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/author | "Langeberg L.K."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/author | "Langeberg L.K."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/author | "Alto N.M."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/author | "Alto N.M."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/author | "Soderling S.H."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/author | "Soderling S.H."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/author | "Westphal R.S."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/author | "Westphal R.S."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/pages | "4589-4600"xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/pages | "4589-4600"xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/title | "Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/title | "Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold."xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10970852 | http://purl.uniprot.org/core/volume | "19"xsd:string |