| http://purl.uniprot.org/citations/10978502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10978502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10978502 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported the structure of the human hexokinase type I (HKI) gene and provided direct evidence of an alternative red blood cell-specific exon 1 located in the 5' flanking region of the gene. Three unique HKI mRNA species have also been described in human spermatogenic cells. These mRNAs contain a testis-specific sequence not present in somatic cell HKI, but lack the sequence for the porin-binding domain necessary for HKI to bind to porin on the outer mitochondrial membrane. The present study reports a new mRNA isoform, hHKI-td, isolated from human sperm. hHKI-td mRNA contains both a testis-specific sequence at the 5' end common to the three other mRNA isoforms and an additional unique sequence. Screening of a cosmid library and analysis of the cosmids containing the HKI gene revealed that testis-specific sequences are encoded by six different exons. Five of these exons are located upstream from the somatic exon 1 (5.6-30 kb) and one within intron 1. This study shows that a single human HKI gene spanning at least 100 kb encodes multiple transcripts that are generated by alternative splicing of different 5' exons. Testis-specific transcripts are probably produced by a separate promoter that induces the expression of the HKI gene in spermatogenic cells."xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0167-4781(00)00147-0"xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0167-4781(00)00147-0"xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/author | "Magnani M."xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/author | "Magnani M."xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/author | "Andreoni F."xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/author | "Andreoni F."xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/author | "Ruzzo A."xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/author | "Ruzzo A."xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/pages | "19-26"xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/pages | "19-26"xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/title | "Structure of the 5' region of the human hexokinase type I (HKI) gene and identification of an additional testis-specific HKI mRNA."xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/title | "Structure of the 5' region of the human hexokinase type I (HKI) gene and identification of an additional testis-specific HKI mRNA."xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/volume | "1493"xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://purl.uniprot.org/core/volume | "1493"xsd:string |
| http://purl.uniprot.org/citations/10978502 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10978502 |
| http://purl.uniprot.org/citations/10978502 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10978502 |
| http://purl.uniprot.org/citations/10978502 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10978502 |
| http://purl.uniprot.org/citations/10978502 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10978502 |