| http://purl.uniprot.org/citations/10987819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10987819 | http://www.w3.org/2000/01/rdf-schema#comment | "The daily rhythm in circulating melatonin is driven by a circadian rhythm in the expression of the arylalkylamine N:-acetyltransferase gene in the rat pineal gland. Turning off expression of this gene at the end of night is believed to involve inhibitory transcription factors, among which Fos-related antigen 2 (Fra-2) appears as a good candidate. Circadian rhythms in the expression of three proteins of activating protein-1 (AP-1) complexes, namely, Fra-2, c-Jun, and Jun-D, are shown here to account for circadian variations in AP-1 binding activity. Quantitative variations in the Fra-2 component over the circadian cycle were associated with qualitative variations in protein isoforms. Destruction of the suprachiasmatic nucleus resulted in decreased nocturnal AP-1 activity, showing that AP-1 circadian rhythm is driven by this nucleus. Exposure to light during subjective night and administration of a serotonin 5-HT(1A)/5-HT(7) receptor agonist during subjective day, respectively, induced a 50% decrease and a 50% increase in both AP-1 and Fra-2 expression. These effects were impaired by suprachiasmatic nucleus lesions. These data show that pineal AP-1 binding activity, which results from Fra-2 expression, can be modulated by light and serotonin through the suprachiasmatic nucleus according to a "phase dependence" that is characteristic of the rhythm of clock sensitivity to both zeitgebers."xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.2000.0751398.x"xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/author | "Sage D."xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/author | "Guillaumond F."xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/author | "Deprez P."xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/author | "Becquet D."xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/author | "Bosler O."xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/author | "Francois-Bellan A.M."xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/pages | "1398-1407"xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/title | "Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers."xsd:string |
| http://purl.uniprot.org/citations/10987819 | http://purl.uniprot.org/core/volume | "75"xsd:string |
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