| http://purl.uniprot.org/citations/11018012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11018012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11018012 | http://www.w3.org/2000/01/rdf-schema#comment | "The SWI/SNF family of chromatin-remodeling complexes plays a key role in facilitating the binding of specific transcription factors to nucleosomal DNA in diverse organisms from yeast to man. Yet the process by which SWI/SNF and other chromatin-remodeling complexes activate specific subsets of genes is poorly understood. We show that mammalian SWI/SNF regulates transcription from chromatin-assembled genes in a factor-specific manner in vitro. The DNA-binding domains (DBDs) of several zinc finger proteins, including EKLF, interact directly with SWI/SNF to generate DNase I hypersensitivity within the chromatin-assembled beta-globin promoter. Interestingly, we find that two SWI/SNF subunits (BRG1 and BAF155) are necessary and sufficient for targeted chromatin remodeling and transcriptional activation by EKLF in vitro. Remodeling is achieved with only the BRG1-BAF155 minimal complex and the EKLF zinc finger DBD, whereas transcription requires, in addition, an activation domain. In contrast, the BRG1-BAF155 complex does not interact or function with two unrelated transcription factors, TFE3 and NF-kappaB. We conclude that specific domains of certain transcription factors differentially target SWI/SNF complexes to chromatin in a gene-selective manner and that individual SWI/SNF subunits play unique roles in transcription factor-directed nucleosome remodeling."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.828000"xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.828000"xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "Jones K.A."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "Jones K.A."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "Kingston R.E."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "Kingston R.E."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "Emerson B.M."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "Emerson B.M."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "Kadam S."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "Kadam S."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "McAlpine G.S."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "McAlpine G.S."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "Phelan M.L."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/author | "Phelan M.L."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/pages | "2441-2451"xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/pages | "2441-2451"xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/title | "Functional selectivity of recombinant mammalian SWI/SNF subunits."xsd:string |
| http://purl.uniprot.org/citations/11018012 | http://purl.uniprot.org/core/title | "Functional selectivity of recombinant mammalian SWI/SNF subunits."xsd:string |