| http://purl.uniprot.org/citations/11025449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11025449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11025449 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional control at the G1/S-phase transition of the cell cycle requires functional interactions of multimeric promoter regulatory complexes that contain DNA binding proteins, transcriptional cofactors, and/or chromatin modifying enzymes. Transcriptional regulation of the human histone H4/n gene (FO108) is mediated by Interferon Regulatory Factor-2 (IRF-2), as well as other histone gene promoter factors. To identify proteins that interact with cell-cycle regulatory factors, we performed yeast two-hybrid analysis with IRF-2 and identified a novel human protein termed Celtix-1 which binds to IRF-2. Celtix-1 contains several phylogenetically conserved domains, including a bromodomain, which is found in a number of transcriptional cofactors. Using a panel of IRF-2 deletion mutants in yeast two-hybrid assays, we established that Celtix-1 contacts the C-terminus of IRF-2. Celtix-1 directly interacts with IRF-2 based on binding studies with glutathione S-transferase (GST)/IRF-2 fusion proteins, and immunofluorescence studies suggest that Celtix-1 and IRF-2 associate in situ. Celtix-1 is distributed throughout the nucleus in a heterodisperse pattern. A subset of Celtix-1 colocalizes with the hyperacetylated forms of histones H3 and H4, as well as with the hyperphosphorylated, transcriptionally active form of RNA polymerase II. We conclude that the bromodomain protein Celtix-1 is a novel IRF-2 interacting protein that associates with transcriptionally active chromatin in situ."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.org/dc/terms/identifier | "doi:10.1002/1097-4652(200011)185:2<269::aid-jcp12>3.0.co;2-l"xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.org/dc/terms/identifier | "doi:10.1002/1097-4652(200011)185:2<269::aid-jcp12>3.0.co;2-l"xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/author | "Stein G.S."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/author | "Stein G.S."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/author | "Stein J.L."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/author | "Stein J.L."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/author | "van Wijnen A.J."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/author | "van Wijnen A.J."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/author | "Enserink J.M."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/author | "Enserink J.M."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/author | "Staal A."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/author | "Staal A."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/name | "J. Cell. Physiol."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/name | "J. Cell. Physiol."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/pages | "269-279"xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/pages | "269-279"xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/title | "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/title | "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2."xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/volume | "185"xsd:string |
| http://purl.uniprot.org/citations/11025449 | http://purl.uniprot.org/core/volume | "185"xsd:string |