| http://purl.uniprot.org/citations/11025664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11025664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11025664 | http://www.w3.org/2000/01/rdf-schema#comment | "The PML gene of acute promyelocytic leukaemia (APL) encodes a growth- and tumour-suppresor protein that is essential for several apoptotic signals. The mechanisms by which PML exerts its pro-apoptotic function are still unknown. Here we show that PML acts as a transcriptional co-activator with p53. PML physically interacts with p53 both in vitro and in vivo and co-localizes with p53 in the PML nuclear body (PML-NB). The co-activatory role of PML depends on its ability to localize in the PML-NB. p53-dependent, DNA-damage-induced apoptosis, transcriptional activation by p53, the DNA-binding ability of p53, and the induction of p53 target genes such as Bax and p21 upon gamma-irradiation are all impaired in PML-/-primary cells. These results define a new PML-dependent, p53-regulatory pathway for apoptosis and shed new light on the function of PML in tumour suppression."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.org/dc/terms/identifier | "doi:10.1038/35036365"xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.org/dc/terms/identifier | "doi:10.1038/35036365"xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Gu W."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Gu W."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Guo A."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Guo A."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Zhong S."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Zhong S."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Salomoni P."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Salomoni P."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Shih A."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/author | "Shih A."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/pages | "730-736"xsd:string |
| http://purl.uniprot.org/citations/11025664 | http://purl.uniprot.org/core/pages | "730-736"xsd:string |