| http://purl.uniprot.org/citations/11046148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11046148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11046148 | http://www.w3.org/2000/01/rdf-schema#comment | "The latent membrane protein (LMP) 2A of Epstein-Barr virus (EBV) is implicated in the maintenance of viral latency and appears to function in part by inhibiting B-cell receptor (BCR) signaling. The N-terminal cytoplasmic region of LMP2A has multiple tyrosine residues that upon phosphorylation bind the SH2 domains of the Syk tyrosine kinase and the Src family kinase Lyn. The LMP2A N-terminal region also has two conserved PPPPY motifs. Here we show that the PPPPY motifs of LMP2A bind multiple WW domains of E3 protein-ubiquitin ligases of the Nedd4 family, including AIP4 and KIAA0439, and demonstrate that AIP4 and KIAA0439 form physiological complexes with LMP2A in EBV-positive B cells. In addition to a C2 domain and four WW domains, these proteins have a C-terminal Hect catalytic domain implicated in the ubiquitination of target proteins. LMP2A enhances Lyn and Syk ubiquitination in vivo in a fashion that depends on the activity of Nedd4 family members and correlates with destabilization of the Lyn tyrosine kinase. These results suggest that LMP2A serves as a molecular scaffold to recruit both B-cell tyrosine kinases and C2/WW/Hect domain E3 protein-ubiquitin ligases. This may promote Lyn and Syk ubiquitination in a fashion that contributes to a block in B-cell signaling. LMP2A may potentiate a normal mechanism by which Nedd4 family E3 enzymes regulate B-cell signaling."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.22.8526-8535.2000"xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.22.8526-8535.2000"xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Ernberg I."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Ernberg I."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Pawson T."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Pawson T."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Rotin D."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Rotin D."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Gish G."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Gish G."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Ingham R."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Ingham R."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Matskova L."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Matskova L."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Plant P."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Plant P."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Winberg G."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/author | "Winberg G."xsd:string |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11046148 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |