| http://purl.uniprot.org/citations/11054429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11054429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11054429 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA polymerase eta (Poleta) functions in error-free replication of UV-damaged DNA, and in vitro it efficiently bypasses a cis-syn T-T dimer by incorporating two adenines opposite the lesion. Steady state kinetic studies have shown that both yeast and human Poleta are low-fidelity enzymes, and they misincorporate nucleotides with a frequency of 10(-2)-10(-3) on both undamaged and T-T dimer-containing DNA templates. To better understand the role of Poleta in error-free translesion DNA synthesis, here we examine the ability of Poleta to extend from base mismatches. We find that both yeast and human Poleta extend from mismatched base pairs with a frequency of approximately 10(-3) relative to matched base pairs. In the absence of efficient extension of mismatched primer termini, the ensuing dissociation of Poleta from DNA may favor the excision of mismatched nucleotides by a proofreading exonuclease. Thus, we expect DNA synthesis by Poleta to be more accurate than that predicted from the fidelity of nucleotide incorporation alone."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m009049200"xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m009049200"xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/author | "Johnson R.E."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/author | "Johnson R.E."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/author | "Prakash L."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/author | "Prakash L."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/author | "Prakash S."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/author | "Prakash S."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/author | "Washington M.T."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/author | "Washington M.T."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/pages | "2263-2266"xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/pages | "2263-2266"xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/title | "Mismatch extension ability of yeast and human DNA polymerase eta."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/title | "Mismatch extension ability of yeast and human DNA polymerase eta."xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11054429 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11054429 |
| http://purl.uniprot.org/citations/11054429 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11054429 |