| http://purl.uniprot.org/citations/11064457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11064457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11064457 | http://www.w3.org/2000/01/rdf-schema#comment | "Human T-cell leukemia virus type I (HTLV-I) Tax protein persistently stimulates the activity of IkappaB kinase (IKK), resulting in constitutive activation of the transcription factor NF-kappaB. Tax activation of IKK requires physical interaction of this viral protein with the IKK regulatory subunit, IKKgamma. The Tax/IKKgamma interaction allows Tax to engage the IKK catalytic subunits, IKKalpha and IKKbeta, although it remains unclear whether this linker function of IKKgamma is sufficient for supporting the Tax-specific IKK activation. To address this question, we have examined the sequences of IKKgamma required for modulating the Tax/IKK signaling. We demonstrate that when fused to Tax, a small N-terminal fragment of IKKgamma, containing its minimal IKKalpha/beta-binding domain, is sufficient for bringing Tax to and activating the IKK catalytic subunits. Disruption of the IKKalpha/beta-binding activity of this domain abolishes its function in modulating the Tax/IKK signaling. We further demonstrate that direct fusion of Tax to IKKalpha and IKKbeta leads to activation of these kinases. These findings suggest that the IKKgamma-directed Tax/IKK association serves as a molecular trigger for IKK activation."xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203894"xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203894"xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/author | "Xiao G."xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/author | "Xiao G."xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/author | "Sun S.C."xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/author | "Sun S.C."xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/pages | "5198-5203"xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/pages | "5198-5203"xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/title | "Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein."xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/title | "Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein."xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/11064457 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11064457 |
| http://purl.uniprot.org/citations/11064457 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11064457 |
| http://purl.uniprot.org/citations/11064457 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11064457 |
| http://purl.uniprot.org/citations/11064457 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11064457 |
| http://purl.uniprot.org/uniprot/P03409 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11064457 |
| http://purl.uniprot.org/uniprot/Q9Y6K9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11064457 |