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| http://purl.uniprot.org/citations/11072090 | http://www.w3.org/2000/01/rdf-schema#comment | "Nitric oxide (NO) is involved in many physiological and pathological processes in the brain. NO is synthesized from arginine by nitric oxide synthase (NOS), and the citrulline generated as a by-product can be recycled to arginine by argininosuccinate synthetase (AS) and argininosuccinate lyase (AL) via the citrulline-NO cycle. When neuronal PC12 cells differentiated with nerve growth factor were treated with interferon-gamma (IFNgamma) and tumor necrosis factor-alpha (TNFalpha), iNOS and AS mRNAs and proteins were markedly induced, with AL mRNA and protein being weakly induced. Cationic amino acid transporter-1 and -2 were not induced. IFNgamma or TNFalpha alone was ineffective. A large amount of NO (190 microM NO(2)(-) plus NO(3)(-) in culture medium in 24 h) was produced from arginine by cytokine-stimulated cells, and arginine could be replaced by citrulline. iNOS induction and NO production were attenuated by dexamethasone and dibutyryl cAMP and even more strongly so when combined. Therefore, a large amount of NO is produced in cytokine-stimulated PC12 cells following to induction of iNOS and citrulline-arginine recycling is important for NO production."xsd:string |
| http://purl.uniprot.org/citations/11072090 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0169-328x(00)00154-6"xsd:string |
| http://purl.uniprot.org/citations/11072090 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/11072090 | http://purl.uniprot.org/core/author | "Gotoh T."xsd:string |
| http://purl.uniprot.org/citations/11072090 | http://purl.uniprot.org/core/author | "Zhang W.Y."xsd:string |
| http://purl.uniprot.org/citations/11072090 | http://purl.uniprot.org/core/author | "Oyadomari S."xsd:string |
| http://purl.uniprot.org/citations/11072090 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11072090 | http://purl.uniprot.org/core/name | "Brain Res Mol Brain Res"xsd:string |
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| http://purl.uniprot.org/citations/11072090 | http://purl.uniprot.org/core/title | "Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide."xsd:string |
| http://purl.uniprot.org/citations/11072090 | http://purl.uniprot.org/core/volume | "83"xsd:string |
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