| http://purl.uniprot.org/citations/11096264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11096264 | http://www.w3.org/2000/01/rdf-schema#comment | "Low-grade B cell lymphomas of mucosa-associated lymphoid tissue (MALT) represent a distinct clinicopathological entity that arises in a wide variety of extranodal sites. Genetically, MALT lymphomas are characterized by the t(11;18)(q21;q21). The genes involved in this translocation have been identified to be API2 on chromosome 11, which encodes an apoptotic inhibitor, and MALT1, a novel gene on chromosome 18. We identified the t(11;18)(q21;q21) by Southern blot analysis and reverse transcriptase PCR in 42% of a panel of extranodal MALT lymphomas. We also identified the breakpoints within the API2 and MALT1 genes in 7 patients, which revealed a consistent breakpoint after the third baculoviral inhibitor of apoptosis repeat domain within API2, and variable breakpoints in MALT1. We determined the API2/MALT1 fusion transcript in 2 cases by Northern blot analysis and also showed that MALT1 mRNA is constitutively expressed in a variety of human tissues. To understand the functional consequence of the translocation, we determined the pattern of expression of API2 and MALT1 through B lineage differentiation. API2 was expressed only in cell lines which correspond to mature B cells, whereas MALT1 mRNA was detectable in pre-B cells, mature B cells and plasma cells. These results suggest that fusion of MALT1 to API2 mediated by the t(11;18)(q21;q21) may result in an increased inhibition of germinal center B cell apoptosis and subsequent development of MALT lymphomas."xsd:string |
| http://purl.uniprot.org/citations/11096264 | http://purl.org/dc/terms/identifier | "doi:10.1159/000022952"xsd:string |
| http://purl.uniprot.org/citations/11096264 | http://purl.uniprot.org/core/author | "Le Beau M.M."xsd:string |
| http://purl.uniprot.org/citations/11096264 | http://purl.uniprot.org/core/author | "Stoffel A."xsd:string |
| http://purl.uniprot.org/citations/11096264 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11096264 | http://purl.uniprot.org/core/name | "Hum Hered"xsd:string |
| http://purl.uniprot.org/citations/11096264 | http://purl.uniprot.org/core/pages | "1-7"xsd:string |
| http://purl.uniprot.org/citations/11096264 | http://purl.uniprot.org/core/title | "The API2/MALT1 fusion product may lead to germinal center B cell lymphomas by suppression of apoptosis."xsd:string |
| http://purl.uniprot.org/citations/11096264 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/11096264 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11096264 |
| http://purl.uniprot.org/citations/11096264 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11096264 |
| http://purl.uniprot.org/uniprot/Q9UDY8#attribution-B551EE610B4D681D925262D5D1553353 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11096264 |