| http://purl.uniprot.org/citations/11113112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11113112 | http://www.w3.org/2000/01/rdf-schema#comment | "vCLAP, the E10 gene product of equine herpesvirus-2, is a caspase-recruitment domain (CARD)-containing protein that has been shown to induce both apoptosis and NF-kappaB activation in mammalian cells. vCLAP has a cellular counterpart, Bcl10/cCLAP, which is also an activator of apoptosis and NF-kappaB. Recent studies demonstrated that vCLAP activates NF-kappaB through an IkappaB kinase (IKK)-dependent pathway, but the underlying mechanism remains unknown. In this report, we demonstrate that vCLAP associates stably with the IKK complex through direct binding to the C-terminal region of IKKgamma. Consistent with this finding, IKKgamma was found to be essential for vCLAP-induced NF-kappaB activation, and the association between vCLAP and the IKK complex induced persistent activation of the IKKs. Moreover, enforced oligomerization of the isolated C-terminal region of vCLAP, which interacts with IKKgamma, can trigger NF-kappaB activation. Finally, substitution of the C-terminal region of IKKgamma, which interacts with vCLAP, with the CARD of vCLAP or Bcl10 produced a molecule that was able to activate NF-kappaB when ectopically expressed in IKKgamma-deficient cells. These data suggest that vCLAP-induced oligomerization of IKKgamma, which is mediated by the CARD of vCLAP, could be the mechanism by which vCLAP induces activation of NF-kappaB."xsd:string |
| http://purl.uniprot.org/citations/11113112 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c000792200"xsd:string |
| http://purl.uniprot.org/citations/11113112 | http://purl.uniprot.org/core/author | "Alnemri E.S."xsd:string |
| http://purl.uniprot.org/citations/11113112 | http://purl.uniprot.org/core/author | "Srinivasula S.M."xsd:string |
| http://purl.uniprot.org/citations/11113112 | http://purl.uniprot.org/core/author | "Poyet J.L."xsd:string |
| http://purl.uniprot.org/citations/11113112 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11113112 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11113112 | http://purl.uniprot.org/core/pages | "3183-3187"xsd:string |
| http://purl.uniprot.org/citations/11113112 | http://purl.uniprot.org/core/title | "vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma."xsd:string |
| http://purl.uniprot.org/citations/11113112 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11113112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11113112 |
| http://purl.uniprot.org/citations/11113112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11113112 |
| http://purl.uniprot.org/uniprot/Q9Y6K9#attribution-A23955036A5F3ED946BBB5D78F7FD576 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11113112 |
| http://purl.uniprot.org/uniprot/Q9YJN5#attribution-7FDA9725D8B4CF9DBE52DA1EBCD3377F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11113112 |
| http://purl.uniprot.org/uniprot/Q9YJN5#attribution-A23955036A5F3ED946BBB5D78F7FD576 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11113112 |