| http://purl.uniprot.org/citations/11113154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11113154 | http://www.w3.org/2000/01/rdf-schema#comment | "In budding yeast cells, the cytoskeletal polarization and depolarization events that shape the bud are triggered at specific times during the cell cycle by the cyclin-dependent kinase Cdc28p. Polarity establishment also requires the small GTPase Cdc42p and its exchange factor, Cdc24p, but the mechanism whereby Cdc28p induces Cdc42p-dependent polarization is unknown. Here we show that Cdc24p becomes phosphorylated in a cell cycle-dependent manner, triggered by Cdc28p. However, the role of Cdc28p is indirect, and the phosphorylation appears to be catalyzed by the p21-activated kinase family member Cla4p and also depends on Cdc42p and the scaffold protein Bem1p. Expression of GTP-Cdc42p, the product of Cdc24p-mediated GDP/GTP exchange, stimulated Cdc24p phosphorylation independent of cell cycle cues, raising the possibility that the phosphorylation is part of a feedback regulatory pathway. Bem1p binds directly to Cdc24p, to Cla4p, and to GTP-bound Cdc42p and can mediate complex formation between these proteins in vitro. We suggest that Bem1p acts to concentrate polarity establishment proteins at a discrete site, facilitating polarization and promoting Cdc24p phosphorylation at specific times during the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m010546200"xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/author | "Moskow J.J."xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/author | "Lew D.J."xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/author | "Zyla T.R."xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/author | "Irazoqui J.E."xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/author | "Bose I."xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/author | "Bardes E.S."xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/pages | "7176-7186"xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/title | "Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p."xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11113154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11113154 |
| http://purl.uniprot.org/citations/11113154 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11113154 |
| http://purl.uniprot.org/uniprot/P11433#attribution-76E2AE7B8A622257FAF624CFC4D0D5B5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11113154 |
| http://purl.uniprot.org/uniprot/P29366#attribution-76E2AE7B8A622257FAF624CFC4D0D5B5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11113154 |
| http://purl.uniprot.org/uniprot/P29366#attribution-9215867FB251A3A12D05B6731FD93951 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11113154 |
| http://purl.uniprot.org/uniprot/P48562#attribution-76E2AE7B8A622257FAF624CFC4D0D5B5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11113154 |
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| http://purl.uniprot.org/uniprot/#_P19073-mappedCitation-11113154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11113154 |
| http://purl.uniprot.org/uniprot/#_P11433-mappedCitation-11113154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11113154 |
| http://purl.uniprot.org/uniprot/#_P48562-mappedCitation-11113154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11113154 |
| http://purl.uniprot.org/uniprot/#_P29366-mappedCitation-11113154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11113154 |