| http://purl.uniprot.org/citations/11136974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11136974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11136974 | http://www.w3.org/2000/01/rdf-schema#comment | "The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00192-6"xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00192-6"xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/author | "Mao F."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/author | "Mao F."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/author | "Kimelman D."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/author | "Kimelman D."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/author | "Weaver C."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/author | "Weaver C."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/author | "Graham T.A."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/author | "Graham T.A."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/pages | "885-896"xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/pages | "885-896"xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/title | "Crystal structure of a beta-catenin/Tcf complex."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/title | "Crystal structure of a beta-catenin/Tcf complex."xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/11136974 | http://purl.uniprot.org/core/volume | "103"xsd:string |