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http://purl.uniprot.org/citations/11175748http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11175748http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11175748http://www.w3.org/2000/01/rdf-schema#comment"Under conditions of endoplasmic reticulum (ER) stress, mammalian cells induce both translational repression and the unfolded protein response that transcriptionally activates genes encoding ER-resident molecular chaperones. To date, the only known pathway for translational repression in response to ER stress has been the phosphorylation of eIF-2alpha by the double-stranded RNA-activated protein kinase (PKR) or the transmembrane PKR-like ER kinase (PERK). Here we report another pathway in which the ER transmembrane kinase/ribonuclease IRE1beta induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. The evidence suggests that both pathways are important for efficient translational repression during the ER stress response."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.org/dc/terms/identifier"doi:10.1038/35055065"xsd:string
http://purl.uniprot.org/citations/11175748http://purl.org/dc/terms/identifier"doi:10.1038/35055065"xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Kohno K."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Kohno K."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Okuda T."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Okuda T."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Kimata Y."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Kimata Y."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Iwawaki T."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Iwawaki T."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Tsuru A."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Tsuru A."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Hosoda A."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Hosoda A."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Kamigori Y."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Kamigori Y."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Nomura-Furuwatari C."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/author"Nomura-Furuwatari C."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/name"Nat. Cell Biol."xsd:string
http://purl.uniprot.org/citations/11175748http://purl.uniprot.org/core/name"Nat. Cell Biol."xsd:string