| http://purl.uniprot.org/citations/11224571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11224571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11224571 | http://www.w3.org/2000/01/rdf-schema#comment | "Smad proteins mediate the transforming growth factor beta responses. C-terminal phosphorylation of R-Smads leads to the recruitment of Smad4 and the formation of active signaling complexes. We investigated the mechanism of phosphorylation-induced Smad complex formation with an activating pseudo-phosphorylated Smad3. Pseudo-phosphorylated Smad3 has a greater propensity to homotrimerize, and recruits Smad4 to form a heterotrimer containing two Smad3 and one Smad4. The trimeric interaction is mediated through conserved interfaces to which tumorigenic mutations map. Furthermore, a conserved Arg residue within the L3 loop, located near the C-terminal phosphorylation sites of the neighboring subunit, is essential for trimerization. We propose that the phosphorylated C-terminal residues interact with the L3 loop of the neighboring subunit to stabilize the trimer interaction."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.org/dc/terms/identifier | "doi:10.1038/84995"xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.org/dc/terms/identifier | "doi:10.1038/84995"xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "Qin B."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "Qin B."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "Lin K."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "Lin K."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "Lam S.S."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "Lam S.S."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "de Caestecker M.P."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "de Caestecker M.P."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "Correia J.J."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "Correia J.J."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "Chacko B.M."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/author | "Chacko B.M."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/pages | "248-253"xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/pages | "248-253"xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/title | "The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization."xsd:string |
| http://purl.uniprot.org/citations/11224571 | http://purl.uniprot.org/core/title | "The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization."xsd:string |