| http://purl.uniprot.org/citations/11258703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11258703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11258703 | http://www.w3.org/2000/01/rdf-schema#comment | "The MCM proteins are essential for the initiation of DNA replication. We have isolated an MCM3-associated protein (MCM3AP) in a two-hybrid screen using MCM3. Here we demonstrate that MCM3AP is an acetyltransferase which acetylates MCM3 and that chromatin-bound MCM3 is acetylated in vivo. The MCM3 acetylase, MCM3AP, is also chromatin-bound. This study also indicates that MCM3AP contains putative acetyl CoA binding motifs conserved within the GCN5-related N-acetyltransferase superfamily. Mutation of those motifs significantly inhibits the MCM3 acetylase activity. Over-expression of MCM3AP inhibits DNA replication, whereas mutation of the acetylase motifs abolishes this effect, suggesting that acetylation plays a role in DNA replication. Taken together, we suggest that MCM3 acetylation is a novel pathway which might regulate DNA replication."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.org/dc/terms/identifier | "doi:10.1093/embo-reports/kve026"xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.org/dc/terms/identifier | "doi:10.1093/embo-reports/kve026"xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Kouzarides T."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Kouzarides T."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Takei Y."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Takei Y."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Tsujimoto G."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Tsujimoto G."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Tanoue A."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Tanoue A."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Laskey R."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Laskey R."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Swietlik M."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/author | "Swietlik M."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/pages | "119-123"xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/pages | "119-123"xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/title | "MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3."xsd:string |
| http://purl.uniprot.org/citations/11258703 | http://purl.uniprot.org/core/title | "MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3."xsd:string |