| http://purl.uniprot.org/citations/11259440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11259440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11259440 | http://www.w3.org/2000/01/rdf-schema#comment | "Bax is a proapoptotic member of the Bcl-2 protein family that commits the cell to undergo programmed cell death in response to apoptotic stimuli. To gain further insights into Bax mechanisms, we have identified a novel Bax-binding protein, termed Bif-1, by using a yeast two-hybrid cloning technique. Bif-1 is an evolutionarily conserved cytoplasmic protein that contains a predicted Src homology 3 (SH3) domain located near its C terminus but shares no significant homology with members of the Bcl-2 family. A Northern blot analysis indicates that Bif-1 is expressed in most tissues with abundant expression in heart and skeletal muscle. Bif-1 is capable of interacting with Bax as demonstrated by yeast two-hybrid, coimmunoprecipitation, and immunofluorescence studies. Induction of apoptosis in murine pre-B hematopoietic cells FL5.12 by interleukin-3 withdrawal results in increased association of Bax with Bif-1, which is accompanied by a conformational change in the Bax protein. Overexpression of Bif-1 promotes Bax conformational change, caspase activation, and apoptotic cell death in FL5.12 cells following interleukin-3 deprivation. Bif-1 thus represents a new type of regulator of Bax-mediated signaling pathways for apoptosis."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m101527200"xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m101527200"xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Komatsu K."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Komatsu K."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Singh S."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Singh S."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Yamada M."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Yamada M."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Yamaguchi H."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Yamaguchi H."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Wang H.-G."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Wang H.-G."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Miyashita T."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Miyashita T."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Cuddeback S.M."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/author | "Cuddeback S.M."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11259440 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |