| http://purl.uniprot.org/citations/11331585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11331585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11331585 | http://www.w3.org/2000/01/rdf-schema#comment | "PACS-1 is a cytosolic protein involved in controlling the correct subcellular localization of integral membrane proteins that contain acidic cluster sorting motifs, such as furin and human immunodeficiency virus type 1 (HIV-1) NEF: We have now investigated the interaction of PACS-1 with heterotetrameric adaptor complexes. PACS-1 associates with both AP-1 and AP-3, but not AP-2, and forms a ternary complex between furin and AP-1. A short sequence within PACS-1 that is essential for binding to AP-1 has been identified. Mutation of this motif yielded a dominant-negative PACS-1 molecule that can still bind to acidic cluster motifs on cargo proteins but not to adaptor complexes. Expression of dominant-negative PACS-1 causes a mislocalization of both furin and mannose 6-phosphate receptor from the trans-Golgi network, but has no effect on the localization of proteins that do not contain acidic cluster sorting motifs. Furthermore, expression of dominant-negative PACS-1 inhibits the ability of HIV-1 Nef to downregulate MHC-I. These studies demonstrate the requirement for PACS-1 interactions with adaptor proteins in multiple processes, including secretory granule biogenesis and HIV-1 pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.9.2191"xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.9.2191"xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Xiang Y."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Xiang Y."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Thomas L."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Thomas L."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Tooze S.A."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Tooze S.A."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Austin C."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Austin C."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Crump C.M."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Crump C.M."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Gu F."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/author | "Gu F."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/pages | "2191-2201"xsd:string |
| http://purl.uniprot.org/citations/11331585 | http://purl.uniprot.org/core/pages | "2191-2201"xsd:string |