| http://purl.uniprot.org/citations/11342626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11342626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11342626 | http://www.w3.org/2000/01/rdf-schema#comment | "Cot/Tpl-2 kinase, homologous to members of mitogen-activated protein kinase kinase kinase, was initially discovered by its capacity to promote cell transformation. Cot/Tpl-2 mRNA levels are increased during G(0) to G(1) phase progression in T lymphocytes, suggesting a role for this kinase later on in the cell cycle. The IL-2-dependent CTLL-2 cells were used to investigate the role of Cot kinase in G(1) to S phase transition. Transient expression of Cot kinase in CTLL-2 cells increases DNA synthesis triggered by IL-2 and the transient expression of a dominant negative form of Cot kinase in CTLL-2 markedly reduces the DNA synthesis triggered by this cytokine. Cell cycle analysis of synchronized CTLL-2 stabling overexpressing Cot kinase indicates that this kinase contributes to the passage to S and G(2)-M phases of the cell cycle. Cot kinase reduces the levels of the cyclin kinase inhibitor p27(kip), whereas bcl-x(L) expression is unaffected. Cot kinase also increases E2F transcriptional activity in a phosphatidylinositol 3 kinase-independent way and acts in synergy with this kinase. These data give evidence, for the first time, of the regulation of different G(1) progression events by Cot kinase."xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.166.10.6084"xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.166.10.6084"xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/author | "Alemany S."xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/author | "Alemany S."xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/author | "Velasco-Sampayo A."xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/author | "Velasco-Sampayo A."xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/pages | "6084-6090"xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/pages | "6084-6090"xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/title | "p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells."xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/title | "p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells."xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/11342626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11342626 |
| http://purl.uniprot.org/citations/11342626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11342626 |
| http://purl.uniprot.org/citations/11342626 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11342626 |
| http://purl.uniprot.org/citations/11342626 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11342626 |
| http://purl.uniprot.org/uniprot/P41279 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11342626 |
| http://purl.uniprot.org/uniprot/P41279#attribution-0C88A6EE4299B5AB2C99B4060E4BA4B6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11342626 |