| http://purl.uniprot.org/citations/11346652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11346652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11346652 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of the transcription factor nuclear factor-kappa B (NF-kappa B) has been found to play an essential role in the inhibition of tumor necrosis factor (TNF)-mediated apoptosis. NF-kappa B regulates several antiapoptotic molecules including inhibitors of apoptosis, Bcl-2 family proteins (A1 and Bcl-X(L))(,) and IEX-IL. Here we report that the expression of a small death effector domain (DED)-containing protein, NDED (NF-kappa B-inducible DED-containing protein), depends on the activation of NF-kappa B. The inhibition of NF-kappa B by I kappa B alpha, a natural inhibitor of NF-kappa B, suppressed NDED mRNA expression induced by TNF. The restoration of NDED in NF-kappa B null cells inhibited TNF-induced apoptosis. Intriguingly, unlike the caspase-8 inhibitor cellular FADD-like interleukin-1 beta converting enzyme-inhibitory protein (c-FLIP), NDED suppressed TNF-mediated apoptosis by inhibiting TNF-induced caspase-8 enzymatic activity but not the processing of caspase-8. Furthermore, NDED could not inhibit etoposide-mediated apoptosis that is independent of caspase-8 activation. Our results provide the first demonstration that NF-kappa B transcriptionally induces the DED-containing protein to suppress TNF-mediated apoptosis by inhibiting caspase-8 activity, which offers new insight into the antiapoptotic mechanism of NF-kappa B."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m102464200"xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m102464200"xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/author | "Wang C.-Y."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/author | "Wang C.-Y."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/author | "You Z."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/author | "You Z."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/author | "Ouyang H."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/author | "Ouyang H."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/author | "Lopatin D."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/author | "Lopatin D."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/author | "Polver P.J."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/author | "Polver P.J."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/pages | "26398-26404"xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/pages | "26398-26404"xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/title | "Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/title | "Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity."xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11346652 | http://purl.uniprot.org/core/volume | "276"xsd:string |