RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/11352648http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11352648http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11352648http://www.w3.org/2000/01/rdf-schema#comment"ApoB mRNA editing is mediated by an editosome complex with apobec-1 as its catalytic component. By yeast two-hybrid cloning using apobec-1 as bait we identified a 69.6-kDa RNA binding protein, GRY-RBP, that contains 3 RNA-recognition motifs (RRMs) as a novel apobec-1 associating protein. GRY-RBP may be an alternatively spliced species of NASP1, a protein of known function. GRY-RBP was shown to bind to apobec-1, the catalytic component of apoB mRNA editosome, in vivo and in vitro. Immunodepletion using a monospecific rabbit antibody abolished editing in apobec-1 expressing HepG2 S-100 extracts. GRY-RBD interacted with apobec-1 through its C-terminus. It contains three RRM (RNA recognition motifs) domains that are homologous to those found in human ACF (apobec-1 complementation factor). Phylogeny analysis of the RRM domain-containing proteins indicates that GRY-RBP clusters with hnRNP-R, ACF, and ABBP-1 (another apobec-1 binding protein). In addition to its involvement with apobec-1 editosome, the suggested cellular functions of GRY-RBD and its structural homologues include RNA transport and RNA secondary structure stabilization."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.2001.4679"xsd:string
http://purl.uniprot.org/citations/11352648http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.2001.4679"xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/author"Chan L."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/author"Chan L."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/author"Chang B.-H."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/author"Chang B.-H."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/author"Lau P.P."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/author"Lau P.P."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/pages"977-983"xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/pages"977-983"xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/title"Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/title"Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome."xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/volume"282"xsd:string
http://purl.uniprot.org/citations/11352648http://purl.uniprot.org/core/volume"282"xsd:string
http://purl.uniprot.org/citations/11352648http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11352648
http://purl.uniprot.org/citations/11352648http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11352648
http://purl.uniprot.org/citations/11352648http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11352648
http://purl.uniprot.org/citations/11352648http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11352648