| http://purl.uniprot.org/citations/11353842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11353842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11353842 | http://www.w3.org/2000/01/rdf-schema#comment | "The docking protein FRS2 is a major downstream effector that links fibroblast growth factor (FGF) and nerve growth factor receptors with the Ras/mitogen-activated protein kinase signaling cascade. In this report, we demonstrate that FRS2 also plays a pivotal role in FGF-induced recruitment and activation of phosphatidylinositol 3-kinase (PI3-kinase). We demonstrate that tyrosine phosphorylation of FRS2alpha leads to Grb2-mediated complex formation with the docking protein Gab1 and its tyrosine phosphorylation, resulting in the recruitment and activation of PI3-kinase. Furthermore, Grb2 bound to tyrosine-phosphorylated FRS2 through its SH2 domain interacts primarily via its carboxyl-terminal SH3 domain with a proline-rich region in Gab1 and via its amino-terminal SH3 domain with the nucleotide exchange factor Sos1. Assembly of FRS2alpha:Grb2:Gab1 complex induced by FGF stimulation results in activation of PI3-kinase and downstream effector proteins such as the S/T kinase Akt, whose cellular localization and activity are regulated by products of PI3-kinase. These experiments reveal a unique mechanism for generation of signal diversity by growth factor-induced coordinated assembly of a multidocking protein complex that can activate the Ras/mitogen-activated protein kinase cascade to induce cell proliferation and differentiation, and PI3-kinase to activate a mediator of a cell survival pathway."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.111114298"xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.111114298"xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Guy G.R."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Guy G.R."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Schlessinger J."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Schlessinger J."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Lax I."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Lax I."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Gotoh N."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Gotoh N."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Hadari Y.R."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Hadari Y.R."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Ong S.H."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/author | "Ong S.H."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/pages | "6074-6079"xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/pages | "6074-6079"xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/title | "Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins."xsd:string |
| http://purl.uniprot.org/citations/11353842 | http://purl.uniprot.org/core/title | "Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins."xsd:string |