| http://purl.uniprot.org/citations/11356864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11356864 | http://www.w3.org/2000/01/rdf-schema#comment | "The neurofibromatosis type 1 (NF1) gene encodes a large tumor suppressor protein (neurofibromin). Although it is known to possess Ras GTPase-activating protein (GAP) activity, the cellular role of neurofibromin remains unclear. Here we used yeast two-hybrid screening to identify neurofibromin-interacting proteins. Syndecan-2, a transmembrane heparan sulfate proteoglycan (HSPG), was isolated as a binding partner for two distinct regions of the neurofibromin protein. We subsequently found that neurofibromin can bind all four mammalian syndecans. NF1 interaction requires the transmembrane domain and a membrane-proximal region of the cytoplasmic tail of syndecan, but not the C terminus of syndecan known to bind to CASK, a membrane-associated guanylate kinase (MAGUK). Neurofibromin, syndecans, and CASK have overlapping subcellular distributions in axons and synapses of neurons, as shown by biochemical fractionation and immunostaining. Moreover, neurofibromin exists in a complex with syndecan and CASK in vivo, as evidenced by their coimmunoprecipitation from rat brain. Our findings suggest that interaction with different members of the syndecan family may be a mechanism for localizing neurofibromin to specialized domains of the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.21-11-03764.2001"xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://purl.uniprot.org/core/author | "Sheng M."xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://purl.uniprot.org/core/author | "Hsueh Y.P."xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://purl.uniprot.org/core/author | "Roberts R.G."xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://purl.uniprot.org/core/author | "Roberts A.M."xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://purl.uniprot.org/core/author | "Volta M."xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11356864 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://purl.uniprot.org/core/pages | "3764-3770"xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://purl.uniprot.org/core/title | "Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans."xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11356864 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11356864 |
| http://purl.uniprot.org/citations/11356864 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11356864 |
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| http://purl.uniprot.org/uniprot/#_A0A8I6A466-mappedCitation-11356864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11356864 |