| http://purl.uniprot.org/citations/11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11359801 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice lacking IFN-regulatory factor (IRF)-1 have reduced numbers of mature CD8+ T cells within the thymus and peripheral lymphoid organs, suggesting a critical role of IRF-1 in CD8(+) T cell differentiation. Here we show that endogenous Bcl-2 expression is substantially reduced in IRF-1(-/-)CD8+ thymocytes and that introduction of a human Bcl-2 transgene driven by Emu or lck promoter in IRF-1(-/-) mice restores the CD8(+) T cell development. Restored CD8+ T cells are functionally mature in terms of allogeneic MLR and cytokine production. In contrast to thymus-derived CD8+ T cells, other lymphocyte subsets including NK, NK T, and TCR-gammadelta(+) intestinal intraepithelial lymphocytes, which are also impaired in IRF-1(-/-) mice, are not rescued by expressing human Bcl-2. Our results indicate that IRF-1 differentially regulates the development of these lymphocyte subsets and that survival signals involving Bcl-2 are critical for the development of thymus-dependent CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/11359801 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.166.11.6509"xsd:string |
| http://purl.uniprot.org/citations/11359801 | http://purl.uniprot.org/core/author | "Koyasu S."xsd:string |
| http://purl.uniprot.org/citations/11359801 | http://purl.uniprot.org/core/author | "Ohteki T."xsd:string |
| http://purl.uniprot.org/citations/11359801 | http://purl.uniprot.org/core/author | "Maki C."xsd:string |
| http://purl.uniprot.org/citations/11359801 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11359801 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11359801 | http://purl.uniprot.org/core/pages | "6509-6513"xsd:string |
| http://purl.uniprot.org/citations/11359801 | http://purl.uniprot.org/core/title | "Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/11359801 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/11359801 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11359801 |
| http://purl.uniprot.org/citations/11359801 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11359801 |
| http://purl.uniprot.org/uniprot/P15314#attribution-61FC1C949CD8557F84F97AFD3986E541 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_P10417-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_P15314-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_A8Y5B9-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_D6RH71-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_Q4FK18-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_Q8BQK4-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_Q3U5M1-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_Q5SX13-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_Q5SX14-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_Q5SX15-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |
| http://purl.uniprot.org/uniprot/#_Q5SX16-mappedCitation-11359801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11359801 |