| http://purl.uniprot.org/citations/11389444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11389444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11389444 | http://www.w3.org/2000/01/rdf-schema#comment | "The receptor-regulated Smad proteins are essential intracellular mediators of signal transduction by the transforming growth factor-beta (TGF-beta) superfamily of growth factors and are also important as regulators of gene transcription. Here we describe a new role for TGF-beta-regulated Smad2 and Smad3 as components of a ubiquitin ligase complex. We show that in the presence of TGF-beta signalling, Smad2 interacts through its proline-rich PPXY motif with the tryptophan-rich WW domains of Smurf2, a recently identified E3 ubiquitin ligases. TGF-beta also induces the association of Smurf2 with the transcriptional co-repressor SnoN and we show that Smad2 can function to mediate this interaction. This allows Smurf2 HECT domain to target SnoN for ubiquitin-mediated degradation by the proteasome. Thus, stimulation by TGF-beta can induce the assembly of a Smad2-Smurf2 ubiquitin ligase complex that functions to target substrates for degradation."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.org/dc/terms/identifier | "doi:10.1038/35078562"xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.org/dc/terms/identifier | "doi:10.1038/35078562"xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Wrana J.L."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Wrana J.L."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Luo K."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Luo K."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Wang H.R."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Wang H.R."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Bonni S."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Bonni S."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Stroschein S.L."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Stroschein S.L."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Causing C.G."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Causing C.G."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Kavsak P."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/author | "Kavsak P."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/pages | "587-595"xsd:string |
| http://purl.uniprot.org/citations/11389444 | http://purl.uniprot.org/core/pages | "587-595"xsd:string |