| http://purl.uniprot.org/citations/11389842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11389842 | http://www.w3.org/2000/01/rdf-schema#comment | "Nodal ligands are essential for the patterning of chordate embryos. Genetic evidence indicates that EGF-CFC factors are required for Nodal signaling, but the molecular basis for this requirement is unknown. We have investigated the role of Cripto, an EGF-CFC factor, in Nodal signaling. We find that Cripto interacts with the type I receptor ALK4 via the conserved CFC motif in Cripto. Cripto interaction with ALK4 is necessary both for Nodal binding to the ALK4/ActR-IIB receptor complex and for Smad2 activation by Nodal. We also find that Nodal can inhibit BMP signaling by a Cripto-independent mechanism. Inhibition appears to be mediated by heterodimerization between Nodal and BMPs, indicating that antagonism between Nodal and BMPs can occur at the level of dimeric ligand production."xsd:string |
| http://purl.uniprot.org/citations/11389842 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00249-0"xsd:string |
| http://purl.uniprot.org/citations/11389842 | http://purl.uniprot.org/core/author | "Whitman M."xsd:string |
| http://purl.uniprot.org/citations/11389842 | http://purl.uniprot.org/core/author | "Yeo C."xsd:string |
| http://purl.uniprot.org/citations/11389842 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11389842 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/11389842 | http://purl.uniprot.org/core/pages | "949-957"xsd:string |
| http://purl.uniprot.org/citations/11389842 | http://purl.uniprot.org/core/title | "Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/11389842 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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