| http://purl.uniprot.org/citations/11390368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11390368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11390368 | http://www.w3.org/2000/01/rdf-schema#comment | "Procaspase-9 contains an NH2-terminal caspase-associated recruitment domain (CARD), which is essential for direct association with Apaf-1 and activation. Procaspase-1 also contains an NH2-terminal CARD domain, suggesting that its mechanism of activation, like that of procaspase-9, involves association with an Apaf-1-related molecule. Here we describe the identification of a human Apaf-1-related protein, named Ipaf that contains an NH2-terminal CARD domain, a central nucleotide-binding domain, and a COOH-terminal regulatory leucine-rich repeat domain (LRR). Ipaf associates directly and specifically with the CARD domain of procaspase-1 through CARD-CARD interaction. A constitutively active Ipaf lacking its COOH-terminal LRR domain can induce autocatalytic processing and activation of procaspase-1 and caspase-1-dependent apoptosis in transfected cells. Our results suggest that Ipaf is a specific and direct activator of procaspase-1 and could be involved in activation of caspase-1 in response to pro-inflammatory and apoptotic stimuli."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c100250200"xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c100250200"xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Alnemri E.S."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Alnemri E.S."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Poyet J.-L."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Poyet J.-L."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Fernandes-Alnemri T."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Fernandes-Alnemri T."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Srinivasula S.M."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Srinivasula S.M."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Razmara M."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Razmara M."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Tnani M."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/author | "Tnani M."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/pages | "28309-28313"xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/pages | "28309-28313"xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/title | "Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1."xsd:string |
| http://purl.uniprot.org/citations/11390368 | http://purl.uniprot.org/core/title | "Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1."xsd:string |