| http://purl.uniprot.org/citations/11390610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11390610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11390610 | http://www.w3.org/2000/01/rdf-schema#comment | "Human T-cell leukemia virus type 1 (HTLV-1) establishes a persistent infection in the host despite a vigorous virus-specific immune response. Here we demonstrate that an HTLV-1-encoded protein, p12(I), resides in the endoplasmic reticulum (ER) and Golgi and physically binds to the free human major histocompatibility complex class I heavy chains (MHC-I-Hc) encoded by the HLA-A2, -B7, and -Cw4 alleles. As a result of this interaction, the newly synthesized MHC-I-Hc fails to associate with beta(2)-microglobulin and is retrotranslocated to the cytosol, where it is degraded by the proteasome complex. Targeting of the free MHC-I-Hc, and not the MHC-I-Hc-beta(2)-microglobulin complex, by p12(I) represents a novel mechanism of viral interference and disrupts the intracellular trafficking of MHC-I, which results in a significant decrease in surface levels of MHC-I on human T-cells. These findings suggest that the interaction of p12(I) with MHC-1-Hc may interfere with antigen presentation in vivo and facilitate escape of HTLV-1-infected cells from immune recognition."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.75.13.6086-6094.2001"xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.75.13.6086-6094.2001"xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Franchini G."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Franchini G."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Johnson J.M."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Johnson J.M."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Casareto L."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Casareto L."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Ciminale V."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Ciminale V."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Fullen J."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Fullen J."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Jacobson S."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Jacobson S."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Mulloy J.C."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Mulloy J.C."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Nicot C."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/author | "Nicot C."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/11390610 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |